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Home > Diseases and Conditions > FSGS > FSGS Basics >

FSGS: Diagnosis and Treatment Principles

FSGS: Diagnosis and Treatment PrinciplesFSGS, or focal segmental glomerular slcerosis, is a kind of kidney disease, with lesions in parts of glomeruli or parts of the glomerular capillary loops. Protein in urine and nephrotic syndrome are the prominent clinical manifestations, and it will finally develop into end stage kidney failure. So patients need to have early diagnosis and get effective treatment for FSGS, which can help slow down their progression and make a good prognosis for them.

Diagnosis for FSGS:

For most cases, doctor will ask patients to take kidney biopsy to diagnose whether they have FSGS. However, since FSGS is focal and segmental lesions, so kidney biopsy cant help diagnose the disease in some cases, so they need to have repeat renal biopsy.

But here are some gist to help diagnose FSGS.

In early stage of FSGS, patients may have high blood pressure and damages of kidney function, and patients can have the symptoms with the occurrence of FSGS, especially for adults.

2. About 2/3 FSGS patients will have microscopic hematuria.

3. For most of the FSGS patients, their protein in urine is non selectivity.

4. For FSGS patients, if their renal tubules are impaired, their urine will have NAG, retinol conjugated protein, and they can also have elevation of urine lysozyme level and reduced urine osmotic pressure.

5. FSGS patients can also have reduced level of serum IgG, and the falling range is higher than the loss of IgG in urine.

Treatment principles for FSGS:

1. FSGS patients need to have treatment to anti-freezing, antithrombus, lower high blood pressure, lower high cholesterol level, control protein in urine, etc.

2. Protect kidney function: this is the most important treatment for FSGS patients to help prevent or slow down progression of reduced kidney function.

3. Prevent complications: the treatment should also help prevent the possible complications for FSGS patients, which can help improve their illness condition.

Above are the diagnosis and treatment principles for FSGS patients. If you still have any questions, you can ask online doctor, or you can also send e-mail to

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